Automated description from the Alliance of Genome Resources
Exhibits GTPase activator activity and actin binding activity. Involved in several processes, including negative regulation of proteasomal protein catabolic process; regulation of glutamatergic synaptic transmission; and synaptic vesicle endocytosis. Localizes to several cellular components, including the actin cytoskeleton; dendritic spine; and terminal bouton. Used to study syndromic intellectual disability. Human ortholog(s) of this gene implicated in X-linked mental retardation with cerebellar hypoplasia and distinctive facial appearance. Is expressed in several structures, including central nervous system; lung; metanephros; retina; and thymus. Orthologous to human OPHN1 (oligophrenin 1).