Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Tmc1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, it is known to be required for normal function of cochlear hair cells. Mutations in this gene have been associated with progressive postlingual hearing loss and profound prelingual deafness. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Tmc1
  • is located in the following cellular components:
    • external side of plasma membrane ^[3]
    • stereocilium bundle tip ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Tmc1
  • participates in the following biological processes:
    • auditory receptor cell development ^[2]
    • detection of mechanical stimulus involved in sensory perception of sound ^[2]
    • sensory perception of sound ^[1]
• Researchers have inferred, based on genetic interactions, that the gene product of Tmc1
  • participates in the following biological processes:
    • detection of mechanical stimulus involved in sensory perception of sound based on interactions with Tmc2 ^[2]
    • vestibular reflex based on interactions with Tmc2 ^[2]

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Summary text based on GO annotations supported by structural data

• Tmc1 encodes a protein or proteins that contain the following InterPro domains: TMC, indicating that the gene product:
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Tmc1 indicates that it:
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Deol MS et al. (1958) A new gene for deafness in the mouse Heredity, 12:463-6.
2. Kawashima Y et al. (2011) Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes. J Clin Invest, 121:4796-809. (PubMed:22105175)
3. Takayanagi S et al. (2006) Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain. Blood, 107:4317-25. (PubMed:16455951)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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