Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Gopc. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a Golgi protein with a PDZ domain. The PDZ domain is globular and proteins which contain them bind other proteins through short motifs near the C-termini. Mice which are deficient in the orthologous protein have globozoospermia and are infertile. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Gopc
  • participates in the following biological processes:
    • regulation of catalytic activity ^[3]
  • performs the following molecular functions:
    • small GTPase regulator activity ^[3]
  • is located in the following cellular components:
    • Golgi apparatus ^[4]
    • plasma membrane ^[4]
    • synapse ^[5]
• The gene product of Gopc has been shown to bind to the gene products of Becn1, Grid1, Grid2, Rhoq. ^{[2, 3, 5]} Researchers have inferred, based on physical interactions, that the gene product of Gopc
  • performs the following molecular functions:
    • frizzled binding ^[4]
    • protein C-terminus binding ^[4]
    • protein homodimerization activity ^[4]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Gopc
  • participates in the following biological processes:
    • spermatid nucleus differentiation ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Gopc:
  • participates in the following biological processes:
    • protein homooligomerization
  • performs the following molecular functions:
    • ion channel binding
  • is located in the following cellular components:
    • cytoplasm
    • Golgi apparatus
    • membrane
    • protein complex
    • trans-Golgi network transport vesicle

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Gopc indicates that it:
  • participates in the following biological processes:
    • protein transport
    • transport
  • is located in the following cellular components:
    • cell junction
    • cell projection
    • postsynaptic membrane

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References

1. Catena R et al. (2006) Changes in intranuclear chromatin architecture induce bipolar nuclear localization of histone variant H1T2 in male haploid spermatids. Dev Biol, 296:231-238. (PubMed:16765935)
2. Hassel B et al. (2003) CALEB/NGC interacts with the Golgi-associated protein PIST. J Biol Chem, 278:40136-43. (PubMed:12885772)
3. Neudauer CL et al. (2001) PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10. Biochem Biophys Res Commun, 280:541-7. (PubMed:11162552)
4. Yao R et al. (2001) Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled. Biochem Biophys Res Commun, 286:771-8. (PubMed:11520064)
5. Yue Z et al. (2002) A Novel Protein Complex Linking the delta2 Glutamate Receptor and Autophagy. Implications for Neurodegeneration in Lurcher Mice. Neuron, 35:921-933. (PubMed:12372286)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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