Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables ubiquitin ligase-substrate adaptor activity and ubiquitin protein ligase activity. Acts upstream of or within several processes, including common myeloid progenitor cell proliferation; protein destabilization; and regulation of DNA damage checkpoint. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including craniocervical region bone; esophagus; lung; pituitary gland; and sensory organ. Orthologous to human FBXO4 (F-box protein 4).