Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Trib2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Trib2
  • participates in the following biological processes:
    • positive regulation of proteasomal ubiquitin-dependent protein catabolic process ^[1]
  • performs the following molecular functions:
    • transcription factor binding ^{[1, 2]}
    • ubiquitin protein ligase binding ^[1]
    • ubiquitin-protein ligase regulator activity ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Trib2
  • participates in the following biological processes:
    • negative regulation of fat cell differentiation ^[2]
• Based on the experimental annotations above, MGI curators have inferred, that the gene product of Trib2
  • participates in the following biological processes:
    • negative regulation of sequence-specific DNA binding transcription factor activity ^[1]
    • positive regulation of ubiquitin-protein ligase activity ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Trib2:
  • participates in the following biological processes:
    • negative regulation of interleukin-10 biosynthetic process
  • is located in the following cellular components:
    • cytoplasm
    • nucleus

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Summary text based on GO annotations supported by structural data

• Trib2 encodes a protein or proteins that contain the following InterPro domains: Protein kinase, catalytic domain, Protein kinase-like domain, Pseudokinase tribbles family/serine-threonine-protein kinase 40, indicating that the gene product:
  • participates in the following biological processes:
    • protein phosphorylation
  • performs the following molecular functions:
    • ATP binding
    • protein kinase activity
    • transferase activity, transferring phosphorus-containing groups

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Trib2 indicates that it:
  • performs the following molecular functions:
    • protein kinase inhibitor activity
  • is located in the following cellular components:
    • cytoskeleton

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References

1. Dedhia PH et al. (2010) Differential ability of Tribbles family members to promote degradation of C/EBP{alpha} and induce acute myelogenous leukemia. Blood, null:null. (PubMed:20410507)
2. Naiki T et al. (2007) TRB2, a mouse Tribbles ortholog, suppresses adipocyte differentiation by inhibiting AKT and C/EBPbeta. J Biol Chem, 282:24075-82. (PubMed:17576771)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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