Automated description from the Alliance of Genome Resources (Release 4.0)
Enables nuclear export signal receptor activity. Involved in negative regulation of transcription by RNA polymerase II; regulation of proteasomal ubiquitin-dependent protein catabolic process; and ribosomal subunit export from nucleus. Acts upstream of or within several processes, including protein export from nucleus; regulation of centrosome duplication; and regulation of protein export from nucleus. Located in nucleus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; early embryo; nervous system; respiratory system; and sensory organ. Orthologous to human XPO1 (exportin 1).