Automated description from the Alliance of Genome Resources
Exhibits histone methyltransferase activity. Predicted to be involved in several processes, including histone H3-K79 methylation; regulation of receptor signaling pathway via JAK-STAT; and regulation of transcription, DNA-templated. Predicted to localize to the nucleoplasm and protein-containing complex. Used to study dilated cardiomyopathy 1A. Human ortholog(s) of this gene implicated in B- and T-cell mixed leukemia. Orthologous to human DOT1L (DOT1 like histone lysine methyltransferase).