About   Help   FAQ
Gene Ontology Classifications
Symbol
Name
ID
Dot1l
DOT1-like, histone H3 methyltransferase (S. cerevisiae)
MGI:2143886

Go Annotations as Summary Text (Tabular View) (GO Graph)


Automated description from the Alliance of Genome Resources

Exhibits histone methyltransferase activity. Predicted to be involved in several processes, including histone H3-K79 methylation; regulation of receptor signaling pathway via JAK-STAT; and regulation of transcription, DNA-templated. Predicted to localize to the nucleoplasm and protein-containing complex. Used to study dilated cardiomyopathy 1A. Human ortholog(s) of this gene implicated in B- and T-cell mixed leukemia. Orthologous to human DOT1L (DOT1 like histone lysine methyltransferase).



Go Annotations in Tabular Form (Text View) (GO Graph)

Filter annotations by: Aspect  Category  Evidence 

 
 


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement

Filter

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2019
MGI 6.14
The Jackson Laboratory