Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables signaling receptor binding activity and ubiquitin protein ligase activity. Involved in several processes, including cell surface receptor signaling pathway; hematopoietic or lymphoid organ development; and lymphocyte differentiation. Acts upstream of or within B cell apoptotic process and humoral immune response. Is active in cytoplasmic vesicle and nucleus. Used to study Sjogren's syndrome; atopic dermatitis; and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in chronic mucocutaneous candidiasis and psoriasis 13. Orthologous to human TRAF3IP2 (TRAF3 interacting protein 2).