Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cyp4v3. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 2, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the cytochrome P450 hemethiolate protein superfamily which are involved in oxidizing various substrates in the metabolic pathway. It is implicated in the metabolism of fatty acid precursors into n-3 polyunsaturated fatty acids. Mutations in this gene result in Bietti crystalline corneoretinal dystrophy. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cyp4v3:
  • participates in the following biological processes:
    • fatty acid omega-oxidation

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Summary text based on GO annotations supported by structural data

• Cyp4v3 encodes a protein or proteins that contain the following InterPro domains: Cytochrome P450, Cytochrome P450, conserved site, Cytochrome P450, E-class, group I, Cytochrome P450, E-class, group IV, indicating that the gene product:
  • participates in the following biological processes:
    • oxidation-reduction process
  • performs the following molecular functions:
    • heme binding
    • iron ion binding
    • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cyp4v3 indicates that it:
  • participates in the following biological processes:
    • oxidation-reduction process
  • performs the following molecular functions:
    • metal ion binding
    • monooxygenase activity
    • oxidoreductase activity
  • is located in the following cellular components:
    • endoplasmic reticulum
    • integral component of membrane
    • membrane
• Cyp4v3 has been associated with the Enzyme Commission numbers: 1.14.13.-, which implies that the gene product:
  • performs the following molecular functions:
    • 1-hydroxy-2-naphthoate hydroxylase activity
    • 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity
    • 1-methylnaphthalene hydroxylase activity
    • 2-hydroxy-phenylacetate hydroxylase activity
    • 2-methylnaphthalene hydroxylase activity
    • 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity
    • 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity
    • 3,5-xylenol methylhydroxylase activity
    • 3-(3-hydroxyphenyl)propionate hydroxylase activity
    • 3-HSA hydroxylase activity
    • 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity
    • 4-chlorobenzaldehyde oxidase activity
    • 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity
    • 4-hydroxypyridine-3-hydroxylase activity
    • 4-nitrophenol 4-monooxygenase activity
    • 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity
    • 6-hydroxynicotinate 3-monooxygenase activity
    • alpha-pinene monooxygenase [NADH] activity
    • bisphenol A hydroxylase A activity
    • branched-chain dodecylbenzene sulfonate monooxygenase activity
    • carbon disulfide oxygenase activity
    • chlorophenol 4-monooxygenase activity
    • dibenzothiophene monooxygenase activity
    • dimethyl sulfide monooxygenase activity
    • isobutylamine N-hydroxylase activity
    • limonene monooxygenase activity
    • phenanthrene 1,2-monooxygenase activity
    • phenanthrene 3,4-monooxygenase activity
    • phenanthrene 9,10-monooxygenase activity
    • phenylacetate hydroxylase activity
    • salicylate 5-hydroxylase activity
    • styrene monooxygenase activity
    • tetrahydrofuran hydroxylase activity
    • thalianol hydroxylase activity
    • tocotrienol omega-hydroxylase activity
    • toluene 2-monooxygenase activity
    • toluene 3-monooxygenase activity
    • toluene 4-monooxygenase activity
    • toluene-4-sulfonate monooxygenase activity
    • toluene-sulfonate methyl-monooxygenase activity
    • xylene monooxygenase activity
• Annotations directly to for the gene Cyp4v3 indicate that MGI curators have found no experimental data [literature] to support further annotation to this category at this time.

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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