Automated description from the Alliance of Genome Resources (Release 7.1.0)
Predicted to enable clathrin adaptor activity. Predicted to be involved in postsynaptic neurotransmitter receptor internalization and synaptic vesicle endocytosis. Predicted to act upstream of or within endocytosis. Part of AP-2 adaptor complex. Is active in synapse. Human ortholog(s) of this gene implicated in familial hypocalciuric hypercalcemia 3. Orthologous to human AP2S1 (adaptor related protein complex 2 subunit sigma 1).