Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits 6-phosphogluconolactonase activity and glucose-6-phosphate dehydrogenase activity. Involved in pentose-phosphate shunt and regulation of cortisol biosynthetic process. Localizes to sarcoplasmic reticulum. Is expressed in alimentary system; cranium; facial bone primordium; liver; and tooth. Human ortholog(s) of this gene implicated in cortisone reductase deficiency; cortisone reductase deficiency 1; and multiple sclerosis. Orthologous to human H6PD (hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase).