Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Clca5. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer. [provided by RefSeq, Jul 2008]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Clca5
  • participates in the following biological processes:
    • chloride transport ^[1]
    • ion transmembrane transport ^[1]
  • performs the following molecular functions:
    • chloride channel activity ^[1]
    • ligand-gated ion channel activity ^[1]
  • is located in the following cellular components:
    • plasma membrane ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Clca5
  • participates in the following biological processes:
    • chloride transport ^[1]
    • ion transmembrane transport ^[1]
  • performs the following molecular functions:
    • chloride channel activity ^[1]
    • ligand-gated ion channel activity ^[1]

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Clca5 indicates that it:
  • participates in the following biological processes:
    • cell adhesion
    • ion transport
    • transport
  • is located in the following cellular components:
    • cell junction
    • integral to membrane
    • membrane

---

References

1. Evans SR et al. (2004) Molecular and functional analyses of two new calcium-activated chloride channel family members from mouse eye and intestine. J Biol Chem, 279:41792-800. (PubMed:15284223)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---