Automated description from the Alliance of Genome Resources (Release 5.2.2)
Enables DNA helicase activity and DNA polymerase binding activity. Involved in DNA duplex unwinding; DNA metabolic process; and regulation of DNA metabolic process. Acts upstream of or within telomere maintenance. Located in chromosome, telomeric region and nucleus. Is expressed in trophectoderm. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive dyskeratosis congenita 5; female breast cancer; gastric adenocarcinoma; high grade glioma (multiple); and lung disease (multiple). Orthologous to human RTEL1 (regulator of telomere elongation helicase 1).