Automated description from the Alliance of Genome Resources (Release 3.0)
Exhibits transcription factor binding activity. Involved in several processes, including chordate embryonic development; embryonic limb morphogenesis; and regulation of transcription by RNA polymerase II. Localizes to heterochromatin; nucleus; and protein-containing complex. Used to study Duane-radial ray syndrome and otitis media. Human ortholog(s) of this gene implicated in Duane retraction syndrome; Duane-radial ray syndrome; Holt-Oram syndrome; IVIC syndrome; and ventricular septal defect. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human SALL4 (spalt like transcription factor 4).