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Gene Ontology Classifications
Symbol
Name
ID
Sall4
sal-like 4 (Drosophila)
MGI:2139360

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Sall4. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene may be a zinc finger transcription factor. Defects in this gene are a cause of Duane-radial ray syndrome (DRRS). [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Bohm J et al. (2008) Sall1, sall2, and sall4 are required for neural tube closure in mice. Am J Pathol, 173:1455-63. (PubMed:18818376)
  2. Elling U et al. (2006) Murine inner cell mass-derived lineages depend on Sall4 function. Proc Natl Acad Sci U S A, 103:16319-24. (PubMed:17060609)
  3. Kagey MH et al. (2010) Mediator and cohesin connect gene expression and chromatin architecture. Nature, 467:430-5. (PubMed:20720539)
  4. Koshiba-Takeuchi K et al. (2006) Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart. Nat Genet, 38:175-183. (PubMed:16380715)
  5. Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell, 5:420-33. (PubMed:19796622)
  6. Sakaki-Yumoto M et al. (2006) The murine homolog of SALL4, a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates with Sall1 in anorectal, heart, brain and kidney development. Development, 133:3005-13. (PubMed:16790473)
  7. van den Berg DL et al. (2010) An Oct4-centered protein interaction network in embryonic stem cells. Cell Stem Cell, 6:369-81. (PubMed:20362541)
  8. Wilson CH et al. (2012) Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation. EMBO J, 31:2486-97. (PubMed:22510880)
  9. Yamashita K et al. (2007) Mouse homolog of SALL1, a causative gene for Townes-Brocks syndrome, binds to A/T-rich sequences in pericentric heterochromatin via its C-terminal zinc finger domains. Genes Cells, 12:171-82. (PubMed:17295837)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory