Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Slc4a11. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a voltage-regulated, electrogenic sodium-coupled borate cotransporter that is essential for borate homeostasis, cell growth and cell proliferation. Mutations in this gene have been associated with a number of endothelial corneal dystrophies including recessive corneal endothelial dystrophy 2, corneal dystrophy and perceptive deafness, and Fuchs endothelial corneal dystrophy. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Slc4a11
  • participates in the following biological processes:
    • fluid transport ^[1]
    • ion homeostasis ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Slc4a11:
  • participates in the following biological processes:
    • bicarbonate transport
    • borate transmembrane transport
    • borate transport
    • cellular cation homeostasis
    • inorganic anion transport
    • proton transport
    • sodium ion transmembrane transport
    • sodium ion transport
  • performs the following molecular functions:
    • bicarbonate transmembrane transporter activity
    • borate transmembrane transporter activity
    • hydrogen ion channel activity
    • protein dimerization activity
    • sodium channel activity

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Summary text based on GO annotations supported by structural data

• Slc4a11 encodes a protein or proteins that contain the following InterPro domains: Bicarbonate transporter, C-terminal, Bicarbonate transporter, eukaryotic, Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2, Phosphotransferase/anion transporter, indicating that the gene product:
  • participates in the following biological processes:
    • anion transport
    • phosphoenolpyruvate-dependent sugar phosphotransferase system
    • transport
  • performs the following molecular functions:
    • inorganic anion exchanger activity
    • sugar:hydrogen symporter activity
    • transporter activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Slc4a11 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • transport
  • performs the following molecular functions:
    • anion:anion antiporter activity
    • symporter activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane
    • plasma membrane

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References

1. Groger N et al. (2010) SLC4A11 prevents osmotic imbalance leading to corneal endothelial dystrophy, deafness, and polyuria. J Biol Chem, 285:14467-74. (PubMed:20185830)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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