Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits delta14-sterol reductase activity. Involved in cholesterol biosynthetic process and neutrophil differentiation. Localizes to nuclear membrane. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; liver; and lung. Used to study Pelger-Huet anomaly; ichthyosis vulgaris; and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in Greenberg dysplasia; Pelger-Huet anomaly; and primary biliary cholangitis. Orthologous to human LBR (lamin B receptor).