Automated description from the Alliance of Genome Resources
Exhibits delta14-sterol reductase activity. Involved in cholesterol biosynthetic process and neutrophil differentiation. Localizes to the nuclear membrane. Used to study Pelger-Huet anomaly; ichthyosis vulgaris; and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in Pelger-Huet anomaly and primary biliary cirrhosis. Orthologous to human LBR (lamin B receptor).