Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Twsg1. (This text reflects annotations as of Tuesday, May 21, 2013.)

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Twsg1
  • participates in the following biological processes:
    • negative regulation of BMP signaling pathway ^[4]
    • negative regulation of osteoblast differentiation ^[4]
  • is located in the following cellular components:
    • extracellular space ^[4]
• The gene product of Twsg1 has been shown to bind to the gene products of Bmp4, Bmp7, Chrd. ^{[1, 7]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Twsg1
  • participates in the following biological processes:
    • cell differentiation ^[6]
    • embryo development ^[5]
    • forebrain development ^[5]
    • hemopoiesis ^[3]
    • negative regulation of BMP signaling pathway ^[3]
    • ossification ^[3]
    • positive regulation of BMP signaling pathway ^[3]
    • salivary gland morphogenesis ^[2]
• Researchers have inferred, based on genetic interactions, that the gene product of Twsg1
  • participates in the following biological processes:
    • BMP signaling pathway based on interactions with Bmp4 ^[6]
    • camera-type eye development based on interactions with Bmp4 ^[6]
    • forebrain development based on interactions with Bmp4 ^[6]
    • mesoderm formation based on interactions with Bmp7 ^[7]
    • tissue development based on interactions with Bmp4 ^[6]

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Twsg1 indicates that it:
  • participates in the following biological processes:
    • multicellular organismal development
  • is located in the following cellular components:
    • extracellular region

---

References

1. Jasuja R et al. (2004) Cell-surface heparan sulfate proteoglycans potentiate chordin antagonism of bone morphogenetic protein signaling and are necessary for cellular uptake of chordin. J Biol Chem, 279:51289-97. (PubMed:15381701)
2. Melnick M et al. (2006) Embryonic salivary gland dysmorphogenesis in Twisted gastrulation deficient mice. Arch Oral Biol, 51:433-8. (PubMed:16289463)
3. Nosaka T et al. (2003) Mammalian twisted gastrulation is essential for skeleto-lymphogenesis. Mol Cell Biol, 23:2969-80. (PubMed:12665593)
4. Petryk A et al. (2005) Twisted gastrulation and chordin inhibit differentiation and mineralization in MC3T3-E1 osteoblast-like cells. Bone, 36:617-26. (PubMed:15780974)
5. Petryk A et al. (2004) The mammalian twisted gastrulation gene functions in foregut and craniofacial development. Dev Biol, 267:374-86. (PubMed:15013800)
6. Zakin L et al. (2004) Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain development. Development, 131:413-24. (PubMed:14681194)
7. Zakin L et al. (2005) Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm. Development, 132:2489-99. (PubMed:15843411)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---