Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Fzd10. (This text reflects annotations as of Tuesday, May 21, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of August 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on physical interactions, that the gene product of Fzd10
  • performs the following molecular functions:
    • Wnt-protein binding ^[1]
• Researchers have inferred, based on genetic interactions, that the gene product of Fzd10
  • participates in the following biological processes:
    • Wnt receptor signaling pathway based on interactions with Fzd1, Lrp5, Wnt7a ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Fzd10:
  • participates in the following biological processes:
    • brain development
    • canonical Wnt receptor signaling pathway
    • embryo development
    • gonad development
    • negative regulation of Rho GTPase activity
    • non-canonical Wnt receptor signaling pathway via JNK cascade
    • positive regulation of JUN kinase activity
    • positive regulation of Rac GTPase activity
    • regulation of actin cytoskeleton organization
    • regulation of transcription from RNA polymerase II promoter
    • vasculature development
  • performs the following molecular functions:
    • PDZ domain binding
    • Wnt-activated receptor activity
  • is located in the following cellular components:
    • cell projection
    • cell surface
    • cytoplasm
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Fzd10 encodes a protein or proteins that contain the following InterPro domains: Frizzled domain, Frizzled protein, Frizzled-10, Frizzled/secreted frizzled-related protein, GPCR, family 2-like, indicating that the gene product:
  • participates in the following biological processes:
    • cell surface receptor signaling pathway
  • performs the following molecular functions:
    • transmembrane signaling receptor activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Fzd10 indicates that it:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
    • multicellular organismal development
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Wang Z et al. (2005) Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5. Mol Cell Biol, 25:5022-30. (PubMed:15923619)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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