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Gene Ontology Classifications
Symbol
Name
ID
Park7
Parkinson disease (autosomal recessive, early onset) 7
MGI:2135637

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Park7. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of April 4, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
References
  1. Andres-Mateos E et al. (2007) DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proc Natl Acad Sci U S A, 104:14807-12. (PubMed:17766438)
  2. Bjorkblom B et al. (2013) Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity. J Biol Chem, 288:22809-20. (PubMed:23792957)
  3. Chen L et al. (2005) Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice. J Biol Chem, 280:21418-26. (PubMed:15799973)
  4. Choi DH et al. (2011) DJ-1 cleavage by matrix metalloproteinase 3 mediates oxidative stress-induced dopaminergic cell death. Antioxid Redox Signal, 14:2137-50. (PubMed:20969476)
  5. Clements CM et al. (2006) DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc Natl Acad Sci U S A, 103:15091-6. (PubMed:17015834)
  6. Goldberg MS et al. (2005) Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron, 45:489-96. (PubMed:15721235)
  7. Guzman JN et al. (2010) Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature, 468:696-700. (PubMed:21068725)
  8. Hayashi T et al. (2009) DJ-1 binds to mitochondrial complex I and maintains its activity. Biochem Biophys Res Commun, 390:667-72. (PubMed:19822128)
  9. Im JY et al. (2012) DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway. Hum Mol Genet, 21:3013-24. (PubMed:22492997)
  10. Kim RH et al. (2005) Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc Natl Acad Sci U S A, 102:5215-20. (PubMed:15784737)
  11. Krebiehl G et al. (2010) Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. PLoS One, 5:e9367. (PubMed:20186336)
  12. Lee JY et al. (2012) Human DJ-1 and its homologs are novel glyoxalases. Hum Mol Genet, 21:3215-25. (PubMed:22523093)
  13. Ma J et al. (2014) DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis. Biochem J, null:null. (PubMed:24947010)
  14. McNally RS et al. (2011) DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB. J Biol Chem, 286:4098-106. (PubMed:21097510)
  15. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)
  16. Parsanejad M et al. (2014) Regulation of the VHL/HIF-1 pathway by DJ-1. J Neurosci, 34:8043-50. (PubMed:24899725)
  17. Pisani A et al. (2006) Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: role of Na+/K+ ATPase. Neurobiol Dis, 23:54-60. (PubMed:16624565)
  18. Robert G et al. (2012) The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS production. Cell Death Differ, 19:1769-78. (PubMed:22555455)
  19. Waak J et al. (2009) Regulation of astrocyte inflammatory responses by the Parkinson's disease-associated gene DJ-1. FASEB J, 23:2478-89. (PubMed:19276172)
  20. Xiong H et al. (2009) Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J Clin Invest, 119:650-60. (PubMed:19229105)
  21. Yokota T et al. (2003) Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition. Biochem Biophys Res Commun, 312:1342-8. (PubMed:14652021)
  22. Zhang L et al. (2005) Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis. Hum Mol Genet, 14:2063-73. (PubMed:15944198)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement

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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory