Automated description from the Alliance of Genome Resources (Release 4.1.0)
Enables several functions, including NAD-dependent histone deacetylase activity (H3-K9 specific); p53 binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including lipid homeostasis; regulation of cellular biosynthetic process; and regulation of signal transduction. Acts upstream of or within several processes, including behavioral response to starvation; cellular response to leukemia inhibitory factor; and gamete generation. Located in heterochromatin; mitochondrion; and nucleus. Part of protein-containing complex. Is expressed in several structures, including central nervous system; exocrine gland; gonad; heart; and hemolymphoid system gland. Used to study fatty liver disease and nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in Huntington's disease and prostate cancer. Orthologous to human SIRT1 (sirtuin 1).