Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits several functions, including NAD-dependent histone deacetylase activity (H3-K9 specific); p53 binding activity; and transcription coregulator activity. Involved in several processes, including lipid homeostasis; regulation of cellular biosynthetic process; and regulation of signal transduction. Localizes to mitochondrion and nuclear heterochromatin. Predicted to colocalize with ESC/E(Z) complex. Is expressed in several structures, including central nervous system; exocrine gland; gonad; heart; and hemolymphoid system gland. Used to study fatty liver disease and nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in Huntington's disease and prostate cancer. Orthologous to human SIRT1 (sirtuin 1).