Automated description from the Alliance of Genome Resources
Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; NAD-dependent histone deacetylase activity (H3-K9 specific); and enzyme binding activity. Involved in several processes, including lipid homeostasis; regulation of cellular biosynthetic process; and regulation of signal transduction. Localizes to the mitochondrion and nuclear heterochromatin. Predicted to colocalize with the ESC/E(Z) complex. Used to study fatty liver disease and nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in Huntington's disease and prostate cancer. Orthologous to human SIRT1 (sirtuin 1).