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Gene Ontology Classifications
Symbol
Name
ID
Arid1a
AT rich interactive domain 1A (SWI-like)
MGI:1935147

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GO curators for mouse genes have assigned the following annotations to the gene product of Arid1a. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. . () , :. (PubMed:)
  2. Bultman SJ et al. (2005) A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development. Genes Dev, 19:2849-61. (PubMed:16287714)
  3. Chandler RL et al. (2013) ARID1a-DNA interactions are required for promoter occupancy by SWI/SNF. Mol Cell Biol, 33:265-80. (PubMed:23129809)
  4. Hurlstone AF et al. (2002) Cloning and characterization of hELD/OSA1, a novel BRG1 interacting protein. Biochem J, 364:255-64. (PubMed:11988099)
  5. Kozmik Z et al. (2001) Characterization of Mammalian Orthologues of the Drosophila osa Gene: cDNA Cloning, Expression, Chromosomal Localization, and Direct Physical Interaction with Brahma Chromatin-Remodeling Complex. Genomics, 73:140-8. (PubMed:11318604)
  6. Lessard J et al. (2007) An essential switch in subunit composition of a chromatin remodeling complex during neural development. Neuron, 55:201-15. (PubMed:17640523)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory