Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables heparin binding activity and integrin binding activity. Involved in several processes, including negative regulation of tumor necrosis factor production; positive regulation of ERK1 and ERK2 cascade; and positive regulation of protein phosphorylation. Acts upstream of or within cell adhesion. Located in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including brain; eye; heart ventricle; hemolymphoid system; and mesenchyme derived from neural crest. Used to study pigment dispersion syndrome. Human ortholog(s) of this gene implicated in primary localized cutaneous amyloidosis 3. Orthologous to human GPNMB (glycoprotein nmb).