Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits DNA binding activity; histone methyltransferase activity (H3-K9 specific); and promoter-specific chromatin binding activity. Involved in several processes, including histone H3-K9 trimethylation; inner cell mass cell proliferation; and regulation of transcription, DNA-templated. Localizes to nucleus. Colocalizes with nuclear chromatin. Is expressed in several structures, including 1-cell stage embryo; central nervous system; long bone; oocyte; and white fat. Human ortholog(s) of this gene implicated in autistic disorder and lung cancer. Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1).