Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits thiol-dependent ubiquitin-specific protease activity. Involved in Ras protein signal transduction; endosome organization; and protein deubiquitination. Localizes to cytosol; extrinsic component of endosome membrane; and midbody. Colocalizes with acrosomal vesicle. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in ACTH-secreting pituitary adenoma. Orthologous to human USP8 (ubiquitin specific peptidase 8).