Automated description from the Alliance of Genome Resources
Exhibits estradiol 17-beta-dehydrogenase activity. Involved in negative regulation of mRNA splicing, via spliceosome and steroid metabolic process. Predicted to localize to the cytosol and nucleus. Human ortholog(s) of this gene implicated in 46 XY gonadal dysgenesis; leukemia; precursor B lymphoblastic lymphoma/leukemia; and precursor T-lymphoblastic lymphoma/leukemia. Orthologous to several human genes including AKR1C3 (aldo-keto reductase family 1 member C3).