Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits endoribonuclease activity; protein homodimerization activity; and protein serine/threonine kinase activity. Involved in several processes, including IRE1-mediated unfolded protein response; positive regulation of RNA splicing; and protein phosphorylation. Localizes to several cellular components, including AIP1-IRE1 complex; endoplasmic reticulum membrane; and nuclear inner membrane. Is expressed in several structures, including adrenal medulla; brain; genitourinary system; gut; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human ERN1 (endoplasmic reticulum to nucleus signaling 1).