Automated description from the Alliance of Genome Resources
Exhibits endoribonuclease activity; protein homodimerization activity; and protein serine/threonine kinase activity. Involved in several processes, including IRE1-mediated unfolded protein response; positive regulation of RNA splicing; and protein phosphorylation. Localizes to several cellular components, including the AIP1-IRE1 complex; endoplasmic reticulum membrane; and nuclear inner membrane. Is expressed in several structures, including adrenal medulla; brain; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human ERN1 (endoplasmic reticulum to nucleus signaling 1).