Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables RNA endonuclease activity; protein homodimerization activity; and protein serine/threonine kinase activity. Involved in IRE1-mediated unfolded protein response and positive regulation of RNA splicing. Acts upstream of or within endoplasmic reticulum unfolded protein response and intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Located in endoplasmic reticulum membrane; mitochondrion; and nuclear inner membrane. Part of AIP1-IRE1 complex. Is expressed in several structures, including brain; connective tissue; hemolymphoid system gland; long bone; and tooth. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human ERN1 (endoplasmic reticulum to nucleus signaling 1).