Automated description from the Alliance of Genome Resources (Release 5.2.2)
Enables endoribonuclease activity; protein homodimerization activity; and protein serine/threonine kinase activity. Involved in several processes, including IRE1-mediated unfolded protein response; mRNA cleavage; and positive regulation of nitrogen compound metabolic process. Acts upstream of or within endoplasmic reticulum unfolded protein response and intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Located in endoplasmic reticulum membrane; mitochondrion; and nuclear inner membrane. Part of AIP1-IRE1 complex. Is expressed in several structures, including brain; connective tissue; hemolymphoid system gland; long bone; and tooth. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human ERN1 (endoplasmic reticulum to nucleus signaling 1).