Automated description from the Alliance of Genome Resources (Release 4.0)
Exhibits ionotropic glutamate receptor binding activity; protein C-terminus binding activity; and scaffold protein binding activity. A structural constituent of postsynaptic density. Involved in several processes, including learning or memory; modulation of chemical synaptic transmission; and postsynapse organization. Localizes to extrinsic component of cytoplasmic side of plasma membrane; glutamatergic synapse; and neuron spine. Predicted to colocalize with ionotropic glutamate receptor complex and postsynaptic membrane. Is expressed in brain and cerebral cortex. Used to study Phelan-McDermid syndrome; autism spectrum disorder; and schizophrenia. Human ortholog(s) of this gene implicated in Phelan-McDermid syndrome and schizophrenia 15. Orthologous to human SHANK3 (SH3 and multiple ankyrin repeat domains 3).