Automated description from the Alliance of Genome Resources (Release 3.0)
Exhibits ionotropic glutamate receptor binding activity; protein C-terminus binding activity; and scaffold protein binding activity. Involved in several processes, including modulation of chemical synaptic transmission; nervous system development; and postsynaptic membrane organization. Localizes to extrinsic component of cytoplasmic side of plasma membrane; glutamatergic synapse; and neuron spine. Predicted to colocalize with ionotropic glutamate receptor complex and postsynaptic membrane. Used to study Phelan-McDermid syndrome; autism spectrum disorder; and schizophrenia. Human ortholog(s) of this gene implicated in Phelan-McDermid syndrome and schizophrenia 15. Is expressed in brain and cerebral cortex. Orthologous to human SHANK3 (SH3 and multiple ankyrin repeat domains 3).