Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Smoc1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a multi-domain secreted protein that may have a critical role in ocular and limb development. Mutations in this gene are associated with microphthalmia and limb anomalies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Smoc1
  • participates in the following biological processes:
    • extracellular matrix organization ^[1]
    • positive regulation of cell-substrate adhesion ^[1]
  • performs the following molecular functions:
    • extracellular matrix binding ^[1]
  • is located in the following cellular components:
    • basement membrane ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Smoc1
  • participates in the following biological processes:
    • eye development ^[2]
    • limb development ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Smoc1:
  • participates in the following biological processes:
    • eye development
    • limb development
    • regulation of osteoblast differentiation

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Summary text based on GO annotations supported by structural data

• Smoc1 encodes a protein or proteins that contain the following InterPro domains: EF-Hand 1, calcium-binding site, EF-hand-like domain, Kazal-type serine protease inhibitor domain, Proteinase inhibitor I1, Kazal, SPARC/Testican, calcium-binding domain, Thyroglobulin type-1, indicating that the gene product:
  • participates in the following biological processes:
    • signal transduction
  • performs the following molecular functions:
    • calcium ion binding
  • is located in the following cellular components:
    • proteinaceous extracellular matrix

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Smoc1 indicates that it:
  • participates in the following biological processes:
    • cell differentiation
    • multicellular organismal development
  • performs the following molecular functions:
    • metal ion binding
  • is located in the following cellular components:
    • extracellular region
    • proteinaceous extracellular matrix

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References

1. Manabe R et al. (2008) Transcriptome-based systematic identification of extracellular matrix proteins. Proc Natl Acad Sci U S A, 105:12849-54. (PubMed:18757743)
2. Okada I et al. (2011) SMOC1 is essential for ocular and limb development in humans and mice. Am J Hum Genet, 88:30-41. (PubMed:21194678)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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