Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables ubiquitin protein ligase activity and ubiquitin protein ligase binding activity. Involved in positive regulation of vasculogenesis and protein autoubiquitination. Part of Cul2-RING ubiquitin ligase complex and Cul5-RING ubiquitin ligase complex. Is expressed in several structures, including brain; cardiovascular system; extraembryonic component; genitourinary system; and limb. Used to study pre-eclampsia. Orthologous to human ASB4 (ankyrin repeat and SOCS box containing 4).