Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables ubiquitin protein ligase activity. Involved in dendritic transport. Acts upstream of or within several processes, including negative regulation of macromolecule metabolic process; regulation of signal transduction; and regulation of vesicle-mediated transport. Located in dendrite and vesicle. Is expressed in genitourinary system; hippocampus; and retina nuclear layer. Orthologous to human RABGEF1 (RAB guanine nucleotide exchange factor 1).