Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Lgals8. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of June 8, 2012. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Lgals8
  • participates in the following biological processes:
    • plasma cell differentiation ^[2]
    • T cell costimulation ^[1]
  • performs the following molecular functions:
    • carbohydrate binding ^[2]

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Lgals8 indicates that it:
  • is located in the following cellular components:
    • cytoplasm
• Annotations directly to for the gene Lgals8 indicate that MGI curators have found no experimental data [literature] to support further annotation to these categories at this time.

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References

1. Tribulatti MV et al. (2012) Redundant and antagonistic functions of galectin-1, -3, and -8 in the elicitation of T cell responses. J Immunol, 188:2991-9. (PubMed:22357632)
2. Tsai CM et al. (2011) Galectin-1 and galectin-8 have redundant roles in promoting plasma cell formation. J Immunol, 187:1643-52. (PubMed:21753146)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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