Automated description from the Alliance of Genome Resources (Release 5.2.2)
Enables integrin binding activity. Acts upstream of or within Rac protein signal transduction; actin cytoskeleton organization; and negative regulation of cell migration. Located in cytosol. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and integumental system. Used to study otitis media. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human NISCH (nischarin).