Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits integrin binding activity. Involved in Rac protein signal transduction; actin cytoskeleton organization; and negative regulation of cell migration. Localizes to cytosol. Is expressed in several structures, including central nervous system; genitourinary system; liver; lung; and retina. Used to study otitis media. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human NISCH (nischarin).