Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Slc4a4. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Slc4a4
  • participates in the following biological processes:
    • sodium ion transport ^[1]
• The gene product of Slc4a4 has been shown to bind to the gene products of Ahcyl1. ^[2]
• Researchers have inferred, based on genetic interactions, that the gene product of Slc4a4
  • participates in the following biological processes:
    • bicarbonate transport based on interactions with Ahcyl1 ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Slc4a4:
  • participates in the following biological processes:
    • bicarbonate transport
    • inorganic anion transport
    • sodium ion transmembrane transport
  • performs the following molecular functions:
    • sodium:bicarbonate symporter activity

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Summary text based on GO annotations supported by structural data

• Slc4a4 encodes a protein or proteins that contain the following InterPro domains: Bicarbonate transporter, C-terminal, Bicarbonate transporter, cytoplasmic, Bicarbonate transporter, eukaryotic, Phosphotransferase/anion transporter, Sodium bicarbonate cotransporter, indicating that the gene product:
  • participates in the following biological processes:
    • anion transport
    • transport
  • performs the following molecular functions:
    • anion transmembrane transporter activity
    • inorganic anion exchanger activity
    • transporter activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Slc4a4 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • transport
  • performs the following molecular functions:
    • symporter activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane
    • plasma membrane

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References

1. Abuladze N et al. (1998) Molecular cloning, chromosomal localization, tissue distribution, and functional expression of the human pancreatic sodium bicarbonate cotransporter. J Biol Chem, 273:17689-95. (PubMed:9651366)
2. Shirakabe K et al. (2006) IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na+/HCO3- cotransporter 1 (pNBC1). Proc Natl Acad Sci U S A, 103:9542-7. (PubMed:16769890)
3. Yang D et al. (2009) IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct. J Clin Invest, 119:193-202. (PubMed:19033647)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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