Automated description from the Alliance of Genome Resources
Exhibits dGTPase activity. Involved in several processes, including dATP catabolic process; negative regulation of type I interferon-mediated signaling pathway; and protein homotetramerization. Predicted to localize to the nucleoplasm; site of double-strand break; and tetraspanin-enriched microdomain. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome and Chilblain lupus. Orthologous to human SAMHD1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1).