Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits actin filament binding activity and protein homodimerization activity. Involved in centrosome localization; nuclear migration; and regulation of cilium assembly. Localizes to nuclear envelope. Is expressed in several structures, including alimentary system; ear; genitourinary system; musculoskeletal system; and nervous system. Used to study Emery-Dreifuss muscular dystrophy. Human ortholog(s) of this gene implicated in autosomal dominant Emery-Dreifuss muscular dystrophy 4; autosomal recessive spinocerebellar ataxia 8; bipolar disorder; cerebellar ataxia; and muscular dystrophy. Orthologous to human SYNE1 (spectrin repeat containing nuclear envelope protein 1).