Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Kcnq4. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Kcnq4
  • participates in the following biological processes:
    • inner ear morphogenesis ^[1]
    • potassium ion transport ^[1]
    • regulation of ion transmembrane transport ^[1]
    • sensory perception of sound ^[1]
  • performs the following molecular functions:
    • voltage-gated potassium channel activity ^[1]
• Based on the experimental annotations above, MGI curators have inferred, that the gene product of Kcnq4
  • is located in the following cellular components:
    • integral to membrane ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Kcnq4:
  • participates in the following biological processes:
    • negative regulation of synaptic transmission, dopaminergic
    • potassium ion transport
  • performs the following molecular functions:
    • delayed rectifier potassium channel activity
    • potassium channel activity
  • is located in the following cellular components:
    • cytoplasm
    • neuron projection
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Kcnq4 encodes a protein or proteins that contain the following InterPro domains: Ion transport domain, Potassium channel, voltage dependent, KCNQ, Potassium channel, voltage dependent, KCNQ, C-terminal, Potassium channel, voltage dependent, KCNQ4, Voltage-dependent potassium channel, indicating that the gene product:
  • participates in the following biological processes:
    • ion transport
    • transmembrane transport
  • performs the following molecular functions:
    • ion channel activity
  • is located in the following cellular components:
    • membrane
    • voltage-gated potassium channel complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Kcnq4 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • potassium ion transmembrane transport
    • transport
  • performs the following molecular functions:
    • ion channel activity
    • voltage-gated ion channel activity
  • is located in the following cellular components:
    • membrane

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References

1. Kharkovets T et al. (2006) Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness. EMBO J, 25:642-52. (PubMed:16437162)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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