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Gene Ontology Classifications
Symbol
Name
ID
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
MGI:1926387

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cdon. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of December 2, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
References
  1. Allen BL et al. (2007) The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development. Genes Dev, 21:1244-57. (PubMed:17504941)
  2. Bae GU et al. (2009) Cdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiation. Mol Cell Biol, 29:4130-43. (PubMed:19470755)
  3. Cole F et al. (2004) Positive regulation of myogenic bHLH factors and skeletal muscle development by the cell surface receptor CDO. Dev Cell, 7:843-54. (PubMed:15572127)
  4. Kang JS et al. (2004) Netrins and neogenin promote myotube formation. J Cell Biol, 167:493-504. (PubMed:15520228)
  5. Kang JS et al. (2002) BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation. EMBO J, 21:114-24. (PubMed:11782431)
  6. Lu M et al. (2010) N-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblasts. Proc Natl Acad Sci U S A, 107:4212-7. (PubMed:20160094)
  7. Oh JE et al. (2009) Cdo promotes neuronal differentiation via activation of the p38 mitogen-activated protein kinase pathway. FASEB J, 23:2088-99. (PubMed:19244314)
  8. Okada A et al. (2006) Boc is a receptor for sonic hedgehog in the guidance of commissural axons. Nature, 444:369-73. (PubMed:17086203)
  9. Tenzen T et al. (2006) The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev Cell, 10:647-56. (PubMed:16647304)
  10. Zhang W et al. (2009) Ocular abnormalities in mice lacking the immunoglobulin superfamily member Cdo. FEBS J, 276:5998-6010. (PubMed:19754878)
  11. Zhang W et al. (2006) Cortical thinning and hydrocephalus in mice lacking the immunoglobulin superfamily member CDO. Mol Cell Biol, 26:3764-72. (PubMed:16648472)
  12. Zhang W et al. (2006) Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly. Dev Cell, 10:657-65. (PubMed:16647303)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory