Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Rassf5. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Rassf5
  • is located in the following cellular components:
    • nucleus ^[3]
• The gene product of Rassf5 has been shown to bind to the gene products of Hras1, Mdm2, Nras, Rap1a, Stk4. ^{[1, 2, 3, 4, 5, 6]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Rassf5
  • participates in the following biological processes:
    • positive regulation of protein ubiquitination ^[3]

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Summary text based on GO annotations supported by structural data

• Rassf5 encodes a protein or proteins that contain the following InterPro domains: Protein kinase C-like, phorbol ester/diacylglycerol binding, Ras-association, SARAH, indicating that the gene product:
  • participates in the following biological processes:
    • intracellular signal transduction
    • signal transduction

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Rassf5 indicates that it:
  • participates in the following biological processes:
    • apoptotic process
  • performs the following molecular functions:
    • metal ion binding
  • is located in the following cellular components:
    • cytoplasm
    • cytoskeleton
    • microtubule

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References

1. Katagiri K et al. (2003) RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1. Nat Immunol, 4:741-8. (PubMed:12845325)
2. Katagiri K et al. (2006) Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion. Nat Immunol, 7:919-28. (PubMed:16892067)
3. Lee D et al. (2012) Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1. EMBO Rep, 13:163-9. (PubMed:22173032)
4. Ortiz-Vega S et al. (2002) The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1. Oncogene, 21:1381-90. (PubMed:11857081)
5. Stieglitz B et al. (2008) Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II. EMBO J, 27:1995-2005. (PubMed:18596699)
6. Vavvas D et al. (1998) Identification of Nore1 as a potential Ras effector. J Biol Chem, 273:5439-42. (PubMed:9488663)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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