Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Postn. (This text reflects annotations as of Tuesday, May 21, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of January 30, 2006. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Postn
  • participates in the following biological processes:
    • cell adhesion ^[1]
  • performs the following molecular functions:
    • heparin binding ^[3]
  • is located in the following cellular components:
    • proteinaceous extracellular matrix ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Postn
  • participates in the following biological processes:
    • extracellular matrix organization ^[2]
    • regulation of Notch signaling pathway ^[4]
    • tissue development ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Postn:
  • participates in the following biological processes:
    • cell adhesion
  • is located in the following cellular components:
    • extracellular matrix

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Postn indicates that it:
  • is located in the following cellular components:
    • extracellular region
    • Golgi apparatus

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References

1. Horiuchi K et al. (1999) Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta. J Bone Miner Res, 14:1239-49. (PubMed:10404027)
2. Rios H et al. (2005) periostin null mice exhibit dwarfism, incisor enamel defects, and an early-onset periodontal disease-like phenotype. Mol Cell Biol, 25:11131-44. (PubMed:16314533)
3. Sugiura T et al. (1995) Expression and characterization of murine osteoblast-specific factor 2 (OSF-2) in a baculovirus expression system. Protein Expr Purif, 6:305-11. (PubMed:7663166)
4. Tkatchenko TV et al. (2009) Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease. Physiol Genomics, 39:160-8. (PubMed:19723774)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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