Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Zfyve26. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Zfyve26:
  • participates in the following biological processes:
    • cytokinesis
    • double-strand break repair via homologous recombination
  • performs the following molecular functions:
    • phosphatidylinositol-3-phosphate binding
  • is located in the following cellular components:
    • centrosome
    • midbody

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Summary text based on GO annotations supported by structural data

• Zfyve26 encodes a protein or proteins that contain the following InterPro domains: Zinc finger, FYVE-related, Zinc finger, FYVE-type, Zinc finger, FYVE/PHD-type, Zinc finger, RING/FYVE/PHD-type, indicating that the gene product:
  • performs the following molecular functions:
    • metal ion binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Zfyve26 indicates that it:
  • participates in the following biological processes:
    • cell cycle
    • cell division
    • DNA repair
    • response to DNA damage stimulus
  • performs the following molecular functions:
    • lipid binding
    • metal ion binding
  • is located in the following cellular components:
    • cytoplasm
    • cytoskeleton

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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