Automated description from the Alliance of Genome Resources
Predicted to have filamin binding activity; misfolded protein binding activity; and unfolded protein binding activity. Involved in several processes, including branching morphogenesis of an epithelial tube; cilium assembly; and negative regulation of centrosome duplication. Localizes to the MKS complex; cytoplasmic vesicle membrane; and endoplasmic reticulum membrane. Predicted to colocalize with the axoneme. Used to study Joubert syndrome 6; Meckel syndrome; cystic kidney disease; and visceral heterotaxy. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 14; Joubert syndrome 6; Meckel syndrome 3; and nephronophthisis 11. Orthologous to human TMEM67 (transmembrane protein 67).