Automated description from the Alliance of Genome Resources (Release 3.1)
Predicted to have filamin binding activity; misfolded protein binding activity; and unfolded protein binding activity. Involved in several processes, including branching morphogenesis of an epithelial tube; cilium assembly; and negative regulation of centrosome duplication. Localizes to MKS complex; cytoplasmic vesicle membrane; and endoplasmic reticulum membrane. Predicted to colocalize with axoneme. Is expressed in diencephalon; hindbrain lateral wall; metanephros; and organ of Corti. Used to study Joubert syndrome 6; Meckel syndrome; cystic kidney disease; and visceral heterotaxy. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome (multiple); COACH syndrome; Joubert syndrome 6; Meckel syndrome 3; and nephronophthisis 11. Orthologous to human TMEM67 (transmembrane protein 67).