Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cecr2. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of December 12, 2012. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cecr2
  • is located in the following cellular components:
    • nuclear euchromatin ^[5]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Cecr2
  • participates in the following biological processes:
    • cochlea development ^[2]
    • inner ear receptor stereocilium organization ^[2]
    • neural fold formation ^[2]
    • neural tube closure ^{[1, 3]}
    • neural tube development ^[4]
• Researchers have inferred, based on genetic interactions, that the gene product of Cecr2
  • participates in the following biological processes:
    • neural tube closure based on interactions with Vangl2 ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cecr2:
  • participates in the following biological processes:
    • apoptotic process
    • ATP-dependent chromatin remodeling
  • performs the following molecular functions:
    • nucleosome-dependent ATPase activity
  • is located in the following cellular components:
    • ISWI complex
    • nucleus

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References

1. Banting GS et al. (2005) CECR2, a protein involved in neurulation, forms a novel chromatin remodeling complex with SNF2L. Hum Mol Genet, 14:513-24. (PubMed:15640247)
2. Dawe CE et al. (2011) Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development. Dev Dyn, 240:372-83. (PubMed:21246654)
3. Fairbridge NA et al. (2010) Cecr2 mutations causing exencephaly trigger misregulation of mesenchymal/ectodermal transcription factors. Birth Defects Res A Clin Mol Teratol, 88:619-25. (PubMed:20589882)
4. Kooistra MK et al. (2012) Strain-specific modifier genes of Cecr2-associated exencephaly in mice: genetic analysis and identification of differentially expressed candidate genes. Physiol Genomics, 44:35-46. (PubMed:22045912)
5. Tate P et al. (1998) Capturing novel mouse genes encoding chromosomal and other nuclear proteins J Cell Sci, 111:2575-85. (PubMed:9701556)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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