Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables carbonate dehydratase activity. Predicted to be involved in chloride ion homeostasis and one-carbon metabolic process. Predicted to act upstream of or within carbon dioxide transport and regulation of pH. Predicted to be located in apical plasma membrane and basolateral plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in isolated hyperchlorhidrosis and lung non-small cell carcinoma. Orthologous to human CA12 (carbonic anhydrase 12).