Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Rars2. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an arginyl-tRNA synthetase that is found in the mitochondrial matrix. Defects in this gene are a cause of pontocerebellar hypoplasia type 6 (PCH6). [provided by RefSeq, Oct 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Rars2
  • is located in the following cellular components:
    • mitochondrion ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Rars2:
  • performs the following molecular functions:
    • poly(A) RNA binding

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Summary text based on GO annotations supported by structural data

• Rars2 encodes a protein or proteins that contain the following InterPro domains: Aminoacyl-tRNA synthetase, class 1a, anticodon-binding, Aminoacyl-tRNA synthetase, class I, conserved site, Arginine-tRNA ligase, class Ia, Arginyl tRNA synthetase N-terminal domain, DALR anticodon binding, Rossmann-like alpha/beta/alpha sandwich fold, indicating that the gene product:
  • participates in the following biological processes:
    • arginyl-tRNA aminoacylation
    • tRNA aminoacylation for protein translation
  • performs the following molecular functions:
    • aminoacyl-tRNA ligase activity
    • arginine-tRNA ligase activity
    • ATP binding
    • nucleotide binding
  • is located in the following cellular components:
    • cytoplasm

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Rars2 indicates that it:
  • participates in the following biological processes:
    • translation
  • performs the following molecular functions:
    • aminoacyl-tRNA ligase activity
    • ATP binding
    • ligase activity
    • nucleotide binding
• Rars2 has been associated with the Enzyme Commission numbers: 6.1.1.19, which implies that the gene product:
  • performs the following molecular functions:
    • arginine-tRNA ligase activity

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References

1. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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