Automated description from the Alliance of Genome Resources
Exhibits protein heterodimerization activity. Involved in cerebral cortex radially oriented cell migration; protein ubiquitination; and radial glia guided migration of Purkinje cell. Predicted to localize to several cellular components, including the cullin-RING ubiquitin ligase complex; nucleus; and site of DNA damage. Is expressed in several structures, including 1st branchial arch mandibular component; central nervous system; eye; genitourinary system; and limb bud. Orthologous to human CUL5 (cullin 5).