Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable 3'-5' exonuclease activity. Involved in spermatid development. Acts upstream of or within several processes, including epithelial cilium movement involved in extracellular fluid movement; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; and ventricular system development. Located in extracellular region and sperm flagellum. Part of radial spoke. Is expressed in lung epithelium; nasal cavity respiratory epithelium; and nasopharynx epithelium. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human NME5 (NME/NM23 family member 5).