Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Nme5. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of October 24, 2012. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Nme5
  • participates in the following biological processes:
    • negative regulation of apoptotic process ^[2]
    • spermatid development ^[2]
  • is located in the following cellular components:
    • sperm flagellum ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Nme5
  • participates in the following biological processes:
    • epithelial cilium movement ^[3]
    • flagellum assembly ^[3]
    • spermatid development ^{[1, 3]}
    • ventricular system development ^[3]

---

Summary text based on GO annotations supported by structural data

• Nme5 encodes a protein or proteins that contain the following InterPro domains: Dpy-30 motif, Nucleoside diphosphate kinase, Nucleoside-diphosphate kinase-like NDK-H5, indicating that the gene product:
  • participates in the following biological processes:
    • CTP biosynthetic process
    • GTP biosynthetic process
    • nucleoside diphosphate phosphorylation
    • spermatid differentiation
    • UTP biosynthetic process
  • performs the following molecular functions:
    • ATP binding
    • nucleoside diphosphate kinase activity

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Nme5 indicates that it:
  • participates in the following biological processes:
    • cell differentiation
    • multicellular organismal development
    • spermatogenesis
• Annotations directly to for the gene Nme5 indicate that MGI curators have found no experimental data [literature] to support further annotation to this category at this time.

---

References

1. Choi YJ et al. (2009) Nm23-M5 mediates round and elongated spermatid survival by regulating GPX-5 levels. FEBS Lett, 583:1292-8. (PubMed:19303412)
2. Hwang KC et al. (2003) Cloning, sequencing, and characterization of the murine nm23-M5 gene during mouse spermatogenesis and spermiogenesis. Biochem Biophys Res Commun, 306:198-207. (PubMed:12788088)
3. Vogel P et al. (2012) Congenital hydrocephalus in genetically engineered mice. Vet Pathol, 49:166-81. (PubMed:21746835)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---