Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Kif27. (This text reflects annotations as of Tuesday, May 21, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of October 17, 2012. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the KIF27 (kinesin 4) sub-family of the mammalian kinesin family. The gene is an ortholog of the Drosophila Cos2 gene, which plays an important role in the Hedgehog signaling pathway. The encoded protein contains an N-terminal motor domain which includes nucleotide-binding and microtubule-interacting regions, a stalk domain containing a predicted coiled coil motif and a C-terminal tail domain. Alternatively spliced transcript variants have been observed for this gene. Pseudogenes associated with this gene are located on chromosome 9. [provided by RefSeq, Dec 2012]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Kif27
  • participates in the following biological processes:
    • cilium assembly ^[2]
  • is located in the following cellular components:
    • cilium ^[2]
• The gene product of Kif27 has been shown to bind to the gene products of Stk36. ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Kif27
  • participates in the following biological processes:
    • epithelial cilium movement ^[1]
    • ventricular system development ^[1]

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Summary text based on GO annotations supported by structural data

• Kif27 encodes a protein or proteins that contain the following InterPro domains: Kinesin, motor domain, Kinesin, motor region, conserved site, indicating that the gene product:
  • participates in the following biological processes:
    • microtubule-based movement
  • performs the following molecular functions:
    • ATP binding
    • microtubule binding
    • microtubule motor activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Kif27 indicates that it:
  • participates in the following biological processes:
    • cell projection organization
  • performs the following molecular functions:
    • ATP binding
    • nucleotide binding
  • is located in the following cellular components:
    • cell projection
    • cytoplasm
    • cytoskeleton
    • microtubule

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References

1. Vogel P et al. (2012) Congenital hydrocephalus in genetically engineered mice. Vet Pathol, 49:166-81. (PubMed:21746835)
2. Wilson CW et al. (2009) Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis. Nature, 459:98-102. (PubMed:19305393)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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