Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits ATPase activity and protein homodimerization activity. Involved in heterochromatin organization involved in chromatin silencing; inactivation of X chromosome by DNA methylation; and inactivation of X chromosome by heterochromatin assembly. Localizes to Barr body. Predicted to colocalize with nuclear chromosome, telomeric region. Is expressed in several structures, including genitourinary system. Human ortholog(s) of this gene implicated in facioscapulohumeral muscular dystrophy 2. Orthologous to human SMCHD1 (structural maintenance of chromosomes flexible hinge domain containing 1).