Automated description from the Alliance of Genome Resources (Release 5.0.0)
Enables Lys48-specific deubiquitinase activity; Lys63-specific deubiquitinase activity; and thiol-dependent deubiquitinase. Involved in several processes, including negative regulation of stress-activated MAPK cascade; protein deubiquitination; and regulation of tumor necrosis factor-mediated signaling pathway. Acts upstream of or within several processes, including positive regulation of T cell receptor signaling pathway; regulation of lymphocyte differentiation; and ripoptosome assembly involved in necroptotic process. Located in ciliary basal body and ciliary tip. Is expressed in several structures, including alimentary system; lower urinary tract; nose; pituitary gland; and skin. Human ortholog(s) of this gene implicated in Brooke-Spiegler syndrome. Orthologous to human CYLD (CYLD lysine 63 deubiquitinase).