Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits Lys48-specific deubiquitinase activity; Lys63-specific deubiquitinase activity; and thiol-dependent ubiquitin-specific protease activity. Involved in several processes, including protein deubiquitination; regulation of lymphocyte differentiation; and regulation of signal transduction. Localizes to ciliary basal body and ciliary tip. Predicted to colocalize with cytoplasmic microtubule and midbody. Is expressed in several structures, including alimentary system; lower urinary tract; nose; pituitary gland; and skin. Human ortholog(s) of this gene implicated in Brooke-Spiegler syndrome. Orthologous to human CYLD (CYLD lysine 63 deubiquitinase).