Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables K48-linked deubiquitinase activity; K63-linked deubiquitinase activity; and cysteine-type deubiquitinase activity. Involved in several processes, including regulation of cilium assembly; regulation of necroptotic process; and regulation of signal transduction. Acts upstream of or within several processes, including positive regulation of T cell receptor signaling pathway; regulation of lymphocyte differentiation; and ripoptosome assembly involved in necroptotic process. Located in ciliary basal body and ciliary tip. Is expressed in several structures, including alimentary system; lower urinary tract; nose; pituitary gland; and skin. Human ortholog(s) of this gene implicated in Brooke-Spiegler syndrome. Orthologous to human CYLD (CYLD lysine 63 deubiquitinase).