Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Atg7. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of December 11, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, the protein appears to be required for fusion of peroxisomal and vacuolar membranes. The protein shows homology to the ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes. [provided by RefSeq, Jan 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Atg7
  • participates in the following biological processes:
    • positive regulation of protein modification process ^[5]
  • performs the following molecular functions:
    • ubiquitin activating enzyme activity ^[8]
• The gene product of Atg7 has been shown to bind to the gene products of Atg10, Atg12, Gabarap, Map1lc3b, Psma3. ^{[5, 8]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Atg7
  • participates in the following biological processes:
    • adult walking behavior ^[1]
    • autophagy ^{[2, 3, 4, 6, 9]}
    • cardiac muscle cell development ^[6]
    • cellular amino acid metabolic process ^[2]
    • cellular membrane organization ^[3]
    • central nervous system neuron axonogenesis ^[4]
    • cerebellar Purkinje cell layer development ^{[1, 4]}
    • cerebral cortex development ^[1]
    • liver development ^[2]
    • negative regulation of apoptotic process ^{[1, 6]}
    • neurological system process ^[1]
    • neuron projection development ^[3]
    • organelle organization ^[2]
    • post-embryonic development ^{[1, 2]}
    • protein catabolic process ^[2]
    • protein modification by small protein conjugation ^[2]
    • pyramidal neuron development ^[1]
    • regulation of protein ubiquitination ^[1]
    • response to starvation ^[2]
  • performs the following molecular functions:
    • APG12 activating enzyme activity ^[7]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Atg7:
  • participates in the following biological processes:
    • positive regulation of macroautophagy
    • positive regulation of protein modification process
    • protein lipidation
  • performs the following molecular functions:
    • protein homodimerization activity
  • is located in the following cellular components:
    • cytoplasm

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Summary text based on GO annotations supported by structural data

• Atg7 encodes a protein or proteins that contain the following InterPro domains: E1-like protein-activating enzyme Gsa7p/Apg7p, Molybdenum cofactor biosynthesis, MoeB, NAD(P)-binding domain, UBA/THIF-type NAD/FAD binding fold, indicating that the gene product:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • catalytic activity
    • nucleotide binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Atg7 indicates that it:
  • participates in the following biological processes:
    • protein transport
    • transport

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References

1. Komatsu M et al. (2006) Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature, 441:880-4. (PubMed:16625205)
2. Komatsu M et al. (2005) Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol, 169:425-34. (PubMed:15866887)
3. Komatsu M et al. (2007) Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci U S A, 104:14489-94. (PubMed:17726112)
4. Marino G et al. (2010) Autophagy is essential for mouse sense of balance. J Clin Invest, 120:2331-44. (PubMed:20577052)
5. Mizushima N et al. (2002) Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method. FEBS Lett, 532:450-4. (PubMed:12482611)
6. Nakai A et al. (2007) The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med, 13:619-24. (PubMed:17450150)
7. Radoshevich L et al. (2010) ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death. Cell, 142:590-600. (PubMed:20723759)
8. Tanida I et al. (2002) Murine Apg12p Has a Substrate Preference for Murine Apg7p over Three Apg8p Homologs. Biochem Biophys Res Commun, 292:256-62. (PubMed:11890701)
9. Wang QJ et al. (2006) Induction of autophagy in axonal dystrophy and degeneration. J Neurosci, 26:8057-68. (PubMed:16885219)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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