Automated description from the Alliance of Genome Resources (Release 4.1.0)
Enables Atg12 activating enzyme activity and Atg8 activating enzyme activity. Involved in several processes, including autophagy; negative regulation of apoptotic process; and regulation of circadian rhythm. Acts upstream of or within several processes, including central nervous system development; positive regulation of secretion; and regulation of cellular protein metabolic process. Located in axoneme and perinuclear region of cytoplasm. Is expressed in central nervous system and retina. Used to study Parkinson's disease; myelodysplastic syndrome; and systemic lupus erythematosus. Orthologous to human ATG7 (autophagy related 7).