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Gene Ontology Classifications
autophagy related 7

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Atg7. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of October 27, 2014. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, the protein appears to be required for fusion of peroxisomal and vacuolar membranes. The protein shows homology to the ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes. [provided by RefSeq, Jan 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Ch'en IL et al. (2011) Mechanisms of necroptosis in T cells. J Exp Med, 208:633-41. (PubMed:21402742)
  2. Fullgrabe J et al. (2013) The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy. Nature, 500:468-71. (PubMed:23863932)
  3. Komatsu M et al. (2006) Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature, 441:880-4. (PubMed:16625205)
  4. Komatsu M et al. (2005) Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol, 169:425-34. (PubMed:15866887)
  5. Komatsu M et al. (2007) Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci U S A, 104:14489-94. (PubMed:17726112)
  6. Marino G et al. (2010) Autophagy is essential for mouse sense of balance. J Clin Invest, 120:2331-44. (PubMed:20577052)
  7. Mizushima N et al. (2002) Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method. FEBS Lett, 532:450-4. (PubMed:12482611)
  8. Mortensen M et al. (2010) Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo. Proc Natl Acad Sci U S A, 107:832-7. (PubMed:20080761)
  9. Nakai A et al. (2007) The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med, 13:619-24. (PubMed:17450150)
  10. Pampliega O et al. (2013) Functional interaction between autophagy and ciliogenesis. Nature, 502:194-200. (PubMed:24089209)
  11. Patel KK et al. (2013) Autophagy proteins control goblet cell function by potentiating reactive oxygen species production. EMBO J, 32:3130-44. (PubMed:24185898)
  12. Pirooz SD et al. (2014) UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs. Proc Natl Acad Sci U S A, 111:2716-21. (PubMed:24550300)
  13. Radoshevich L et al. (2010) ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death. Cell, 142:590-600. (PubMed:20723759)
  14. Tanida I et al. (2002) Murine Apg12p Has a Substrate Preference for Murine Apg7p over Three Apg8p Homologs. Biochem Biophys Res Commun, 292:256-62. (PubMed:11890701)
  15. Wang QJ et al. (2006) Induction of autophagy in axonal dystrophy and degeneration. J Neurosci, 26:8057-68. (PubMed:16885219)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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